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4/5/2021 2 Comments

Effect of Adaptogens on Nervous System and Stress

Stress is a physiological condition associated with disorders of the nervous, endocrine, and immune systems. Uncovering natural remedies to combat stress continues to be a significant area of scientific research. In traditional Chinese Medicine known as Ayurveda, consumption of adaptogenic herbs is common practice to improve the body’s ability to adjust to exposures such as extreme temperatures, loud noise, strenuous physical exertion, chemical pollutants, and to help maintain cognitive function, blood glucose, lipid levels and blood pressure. Adaptogens are naturally occurring plant compounds or extracts known to exhibit protection against stress, fatigue, anxiety, and depression. According to Selye’s theory (Selye, 1950) the stress response and general adaptation syndrome includes three phases: alarm, resistance, and exhaustion. Recent pharmacological studies of individual adaptogens provide rationale to their effects at the molecular level, indicating several mechanisms of action that help the body maintain equilibrium. However, adaptogens supposedly act non-specifically, and may activate certain energy-producing chemical receptors and deactivate others to prevent overreaction to stress messengers. Combinations of adaptogenic plants may offer unique effects due to their synergistic interactions in organisms which are not achieved by isolated extracts or supplements of individual adaptogens.

The chemical compounds known as adaptogens are typically phenolics or triterpenoids. Phenolics are structurally similar to catecholamines, which activate the stress system in the early stages of stress response. Triterpenoids resemble the corticosteroids that act as stress hormones in deactivation of the stress system. Adaptogens often are included alone or in combinations in bottled beverages, herbal teas, smoothies, plant-based protein powders, and supplements. The following are adaptogens that have demonstrated beneficial health effects:
  • Holy Basil
  • Turmeric
  • Ashwagandha
  • Ginseng
  • Rhodiola
Stress is a part of daily life, and many lifestyle factors, including diet, sleep, physical activity, and mental health practices such as meditation, yoga, Pilates, and deep breathing influence stress management. Although adaptogens may be a promising complementary therapy for stress, future research is needed to evaluate the complex potential of these herbal extracts and their possible effects on human health and longevity. As with all dietary supplements, the FDA advises that consumers consult with a qualified health care professional before taking any botanical or herbal supplement. It is important to be aware that adaptogens aren’t safe for everyone, as they may interfere with certain medications, and their use is contraindicated in pregnant and breastfeeding women because botanicals may alter hormone levels.
References:
Enyeart JA, Liu H, Enyeart JJ. Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion and Ca(v)3.2 current. J Nat Prod. 2009;72(8):1533-1537. 
Jamshidi N, Cohen MM. The clinical efficacy and safety of tulsi in humans: a systematic review of the literature. Evid Based Complement Alternat Med. 2017;2017:9217567. 
Lee S, Rhee DK. Effects of ginseng on stress-related depression, anxiety, and the hypothalamic-pituitary-adrenal axis. J Ginseng Res. 2017;41(4):589-594.
Liao, L. Y., He, Y. F., Li, L., Meng, H., Dong, Y. M., Yi, F., & Xiao, P. G. (2018). A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chinese medicine, 13, 57. https://doi.org/10.1186/s13020-018-0214-9.
Panossian, A., & Wikman, G. (2010). Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals (Basel, Switzerland), 3(1), 188–224. https://doi.org/10.3390/ph301018
Selye H.  Stress. Acta Medical Publisher; Montreal, Canada: 1950.

2 Comments
kodi.software link
1/18/2022 10:00:38 pm

anks for shadcring the article, and mc szor e importantly, your personal experience mindfully using our emotions as data about our inner state and knowing when it’s better to de-esca clate by taking a time out are great tools. Appreciate you reading and sharing your story since I can certainly relate and I think others can to

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CB2 Oil link
4/12/2022 05:24:32 am

Some mushrooms, including reishi, Cordyceps, and lion’s mane, may have adaptogenic properties and help reduce the negative effects of stress on the body. Adaptogens improve the adaptability of the body, regardless of the origin of the stressor (physiological, psychological, environmental, or situational), and increase the body's resistance threshold. Adaptogens aren’t a new concept. It’s been shown to alleviate anxiety, enhance memory & cognition and help the body adapt to physical & mental stressors. New research is looking at how adaptogens like terpene isolate and cb2 oil (https://nuturawellness.com/products/cb2-oil) may be helpful in treating chronic diseases such as respiratory and heart conditions.

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